Faculty of Biology, University of Latvia
EEB
Hard copy: ISSN 1691–8088
On-line: ISSN 2255–9582
Acta Univ Latv (2003) 662: 25–32
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Environmental and
Experimental
Biology

Acta Univ Latv (2003) 662: 25–32

Orginal Article

Tumour suppressor gene CDKN2A/p16 germline mutations in melanoma patients with additional cancer and cancer in their family history

Dace Pjanova1*, Olita Heisele1, Ludmila Engele2, Ingrida Desjatnikova1
1Biomedical Research and Study Centre, University of Latvia, Rātsupītes iela 1, Rīga, LV-1067, Latvia
2Latvian Oncological Center, Hipokrāta iela 4, Rīga, LV-1079, Latvia
*Corresponding author, E-mail: dace@biomed.lu.lv

Abstract

Germline mutations of the tumour suppressor gene CDKN2A/p16 have been reported in association with familial melanoma, sporadic melanoma and pancreatic cancer. We studied the possibility of mutations in the CDKN2A/p16 gene in patients with melanoma and additional unrelated cancer and in patients with additional unrelated cancer in their family history as well. Twenty five melanoma patients with additional cancer and twenty six melanoma patients with additional unrelated cancer in their family history were studied. The entire coding region of the CDKN2A/p16 gene was screened by single stranded conformation polymorphism analyses and direct DNA sequencing. No germline mutations were detected in the observed melanoma patients. The previously described Ala148Thr and 500 C/G polymorphism were detected. It appears that the cancer development in the patients studied is related to a combination of low-risk susceptibility genes and environmental factors.

Key words: Cancer, CDKN2A/p16, melanoma, mutations, polymorphism, tumour suppressor gene.

 
Acta Univ Latv (2003) 662: 25–32
 DOI: http://doi.org/10.22364/eeb
EEB

Editor-in-Chief
Prof. Gederts Ievinsh



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University of Latvia

 
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