Faculty of Biology, University of Latvia
Hard copy: ISSN 1691–8088
On-line: ISSN 2255–9582
Acta Univ Latv (2007) 723: 123–143
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Environmental and

Acta Univ Latv (2007) 723: 123–143

Orginal Article

Is vaccine against HCV possible?

Marija Mihailova1*, Irina Sominskaya1, Sergej Viazov2, Pauls Pumpens1
1Department of Protein Engineering, Latvian Biomedical Research and Study Centre, Rātsupītes 1, Rīga LV-1067, Latvia
2Institute of Virology, Essen University Hospital, Hufelandstr. 55, 45122 Essen, Germany
*Corresponding author, E-mail: mary@biomed.lu.lv


Natural immunity against the hepatitis C virus (HCV) was discovered not long ago. Some infected individuals are able to clear the virus, while other patients need intensive antiviral drug treatment that is expensive and not always effective. For this reason, many efforts are directed towards development of an effective vaccine in order to improve treatment outcome by stimulating humoral and cellular immune responses against HCV proteins or their immunodominant epitopes. Several HCV vaccine candidates have been tested in chimpanzees and promising results have allowed optimism about the development of at least partially effective vaccine against highly heterogeneous HCV pathogen. Hepatitis B virus core particles can be used successfully as a carrier of HCV epitopes. Chimeric HBc/HCV virus-like particles represent an interesting and valuable tool in the development of HCV vaccine.

Key words: hepatitis C virus, immune response, vaccine, virus-like particles.

Acta Univ Latv (2007) 723: 123–143
 DOI: http://doi.org/10.22364/eeb

Prof. Gederts Ievinsh
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University of Latvia

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