Faculty of Biology, University of Latvia
EEB
Hard copy: ISSN 1691–8088
On-line: ISSN 2255–9582
Env Exp Biol (2014) 12: 29–32
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Environmental and
Experimental
Biology

Env Exp Biol (2014) 12: 29–32

Orginal Articles

In vitro antiproliferative and antimicrobial evaluation of Kigelia pinnata

Olubunmi Atolani1,2*, Sunday Oladoye3, Oluyomi S. Adeyemi4, Gabriel A. Olatunji2
1Department of Chemical Sciences, Redeemer’s University, P.M.B. 3005, Redemption Camp, Mowe, Ogun State, Nigeria
2Department of Chemistry, University of Ilorin, P.M.B. 1515, Ilorin, Nigeria
3Department of Pure and Applied Chemistry, Ladoke Akintola University of Technology, Ogbomosho, Nigeria
4Department of Biological Sciences, Landmark University, PMB 1001, Omu-Aran, Nigeria
*Corresponding author, E-mail: tolanvent@yahoo.com; atolanio@run.edu.ng

Abstract

Kigelia pinnata (Lam.) Benth is a multi-medicinal plant with highly valued root extracts that are often applied in folk medicine for the management of various types of cancers and microbial infections. This study evaluates the anti-proliferative and antimicrobial potential of K. pinnata extracts. Oil and extracts from the root were obtained by cold extraction using hexane, ethylacetate and methanol and were concentrated in vacuo and examined for their antimicrobial activities and anti-proliferative activities on human breast cancer cell lines using agar diffusion method and tetrazolium dye assay, respectively. The oil and ethylacetate extract showed little or no antimicrobial activities for all organisms tested except for moderate activity on Aspergillus sp., but the methanol extract showed significant activity against Salmonella typhi, Proteus sp., Rhizopus sp. and Aspergillus sp. Most importantly, the three extracts significantly inhibited the growth of tumour cells in vitro with high cytotoxicity indices, while the ethylacetate extract had the highest potency, with IC50 values of 10.53 ± 1.6 on human breast cancer cell lines. The root extracts showed significant anti-proliferative activity, which supports the folk claims of use of the plant as an anticancer repertoire.

Key words: antimicrobial activity; antiproliferative; cancer cell line; cytotoxicity; Kigelia pinnata; MTT assay.

 
Env Exp Biol (2014) 12: 29–32
 DOI: http://doi.org/10.22364/eeb
EEB

Editor-in-Chief
Prof. Gederts Ievinsh



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