Faculty of Biology, University of Latvia
EEB
Hard copy: ISSN 1691–8088
On-line: ISSN 2255–9582
Env Exp Biol (2014) 12: 131–135
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Environmental and
Experimental
Biology

Env Exp Biol (2014) 12: 131–135

Orginal Articles

Evaluation of antitumor activity of Manilkara zapota leaves against Ehrlich ascites carcinoma in mice

M. Mamunur Rashid, M. Ismail Hossain, M. Abu Osman, M. Abdul Aziz, M. Rowshanul Habib, M. Rezaul Karim*
Department of Biochemistry and Molecular Biology, Rajshahi University, Rajshahi-6205, Bangladesh
*Corresponding author, E-mail: rezaplazad@yahoo.com

Abstract

This study has been designed to explore in vivo the antitumuor activity of the ethyl acetate extract of leaves of Manilkara zapota (EALM) against Ehrlich ascites carcinoma (EAC). The antitumour activity of EALM against EAC was evaluated at doses of 50, 100 and 200 mg kg–1 day–1. Intraperitoneal treatment with EALM (at 100 and 200 mg kg–1 day–1) showed a significant increase in survival time and decrease in viable EAC cell count and weight gain in the EAC tumour hosts. Improvement in the altered hematological parameters following EALM treatment, like hemoglobin content, red blood corpuscle and white blood corpuscle count of the EAC cell bearing mice were also observed. Overall, the findings of the study indicate antitumour activity of EALM. In addition, erythrodiol, which was for the first time isolated from EALM, also showed 70.8% reduction in viable tumour cell count, in comparison with the untreated control.

Key words: antitumour activity, Ehrlich ascites carcinoma, erythrodiol, Manilkara zapota, mice.

 
Env Exp Biol (2014) 12: 131–135
 DOI: http://doi.org/10.22364/eeb
EEB

Editor-in-Chief
Prof. Gederts Ievinsh



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