Faculty of Biology, University of Latvia
EEB
Hard copy: ISSN 1691–8088
On-line: ISSN 2255–9582
Environ Exp Biol (2015) 13: 103–108
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Environmental and
Experimental
Biology

Environ Exp Biol (2015) 13: 103–108

Original paper

Hepatoprotective efficacy of medicinal mushroom Pleurotus tuber-regium

Sukumar Dandapat1,*, M.P. Sinha1, Manoj Kumar2, Yashvir Jaggi3,
1Department of Zoology, Ranchi University, Ranchi-834008, Jharkhand, India
2Department of Zoology, St. Xavier College, Ranchi-834001, Jharkhand, India
3Department of Zoology, Markham College of Commerce, Hazaribagh-825301, Jharkhand, India
*Corresponding author, E-mail: scholar.sukumar27@gmail.com

Abstract

Pleurotus tuber-regium (Rumph. ex Fr.) Singer is a medicinal mushroom traditionally used for curing various diseases. The aim of the present study was to perform chemical screening and analyze hepatoprotective efficacy of P. tuber-regium extracts in CCl4 hepatotoxic rat. The highest concentration in fungal extract was found for alkaloids (28.41 ± 0.5 mg 100 g–1) and the lowest for tannins (2.74 ± 0.28 mg 100 g–1) with flavonoids and phenolics in moderate concentrations. P. tuber-regium extract showed high total antioxidant activity (12.7 and 21.5% at 10 and 50 to 100 µg mL–1, respectively). The activity of aspartate aminotransferase, alanine transaminase, alkaline phosphatase and concentration of bilirubin significantly increased in P. tuber-regium extract-treated hepatotoxic rats while concentration of total protein and serum albumin significantly decreased in comparison to control animals, averting toxic effects of CCl4. As the P. tuber-regium extract possessed no acute oral toxicity, it can be used as hepato protective tonic.

Key words: antioxidant activity, hepatoprotective efficacy, oxidative stress, Pleurotus tuber-regium, mushrooms.

 
Environ Exp Biol (2015) 13: 103–108
 DOI: http://doi.org/10.22364/eeb
EEB

Editor-in-Chief
Prof. Gederts Ievinsh



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