Faculty of Biology, University of Latvia
Hard copy: ISSN 1691–8088
On-line: ISSN 2255–9582
Acta Univ Latv (2006) 710: 41–51
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Environmental and

Acta Univ Latv (2006) 710: 41–51

Orginal Article

Assessment of risk factors in the development of pancreatic cancer in Latvia

Aiga Stāka1,3*, Silvija Skudra2,3*, Aldis Puķītis1,3, Juris Pokrotnieks1, Laima Tihomirova2**
1Pauls Stradiņš Clinical University Hospital, Pilsoņu 13, Rīga LV-1002, Latvia
2Latvian Biomedical Research and Study Centre, Rātsupītes 1, Rīga LV-1067, Latvia
3University of Latvia, Raiņa Bulv. 19, Rīga LV-1050, Latvia
*Equal contribution
**Corresponding author, E-mail: laima@biomed.lu.lv


The aim of the study was to assess the possibility of identifying individuals at risk of pancreatic cancer (PC) on the basis of information from questionnaires filled in by patients and analyses of the DNA from peripheral blood of PC patients for mutations in BRCA1, CDKN2A, INK4/ARF and STK11 genes. Questionnaires showed unknown risk factors in ethiology and pathogenesis of PC besides smoking and other known risk factors. Two carriers of frameshift mutations in the BRCA1 gene of 68 PC patients tested were detected. Screening for two founder mutations in the BRCA1 gene should be carried out in PC patients to identify at least a part of cancer-prone families in order to offer to mutation carriers comprehensive care, surveillance and preventive procedures. No deleterious mutations were detected in CDKN2A, INK4/ARF and STK11 genes. We conclude that mutations in these genes do not contribute significantly to PC incidence in the population of Latvia. The role of missense mutations detected can not be estimated unambigously on the basis of our data.

Key words: genes, mutations, pancreatic cancer, risk factors.

Acta Univ Latv (2006) 710: 41–51
 DOI: http://doi.org/10.22364/eeb

Prof. Gederts Ievinsh
Published by
University of Latvia

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