Faculty of Biology, University of Latvia
Hard copy: ISSN 1691–8088
On-line: ISSN 2255–9582
Environ Exp Biol (2020) 18: 305–311
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Environmental and

Environ Exp Biol (2020) 18: 305–311

Orginal Paper

Assessment of behavioural toxicity in dichlorvos-exposed Caenorhabditis elegans

Sarita Mishra, Rakhi Agarwal*
Laboratory of Analytical & Molecular Toxicology (Forensic Chemistry & Toxicology Laboratory), School of Forensic Science, National Forensic Sciences University, Sector 09, Gandhinagar, 382007, Gujarat, India
* Corresponding author, E-mail: lamt.dct.gfsu@gmail.com


The extensive use of pesticides in agriculture and other household products have raised global health concerns due to their toxicity and adverse effects on humans and other non-target species. Dichlorvos (DDVP), an organophosphate pesticide, has become increasingly popular for its domestic, industrial and agricultural uses, however, it also raises a serious public health concern due to its unregulated and unrestricted use. Therefore, knowing the toxic nature of DDVP will be a great help to use it in a regulated manner. The present study was designed to examine the impact of DDVP exposure on animal behaviour, using a nematode species Caenorhabditis elegans. Exposure to C. elegans with varying concentrations of DDVP (5, 20, 45, 70, 90 µM) for 2 h induced a concentration-dependent reduction in feeding rate and altered locomotion in terms of speed, body bending, head thrashing, omega turn and reversal frequency. Thus, the present study suggested the behavioural toxicity associated with DDVP exposure and use of different behavioural parameters mentioned above as early biomarkers for toxicological studies using C. elegans.

Key words: behavioural toxicity, Caenorhabditis elegans, dichlorvos, early biomarkers, pharyngeal pumping.

Environ Exp Biol (2020) 18: 305–311
 DOI: http://doi.org/10.22364/eeb.18.30

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