Volume 22, Number 2

Nazir S., Yasien U., Ashraf A., Ganie S.A., Bhat A.W. 2024. Unravelling the role of Set2 protein domains in H3K36 methylation in Saccharomyces cerevisiae. Environmental and Experimental Biology 22: 87–93.
DOI: 10.22364/eeb.22.09

Comparison of the protein domains of budding yeast Set2 and human SETD2. The architectural organization of Set2 in budding yeast and its human homolog SETD2 exhibits remarkable conservation of domains: Both proteins feature a highly conserved domain arrangement, including a catalytic SET domain responsible for methyltransferase activity. Adjacent to the SET domain lies the Autoinhibitory Domain (AID), whose precise function remains largely elusive. Following the AID, a tandem arrangement of the WW, coiled-coil (CC) domains, and Set2-Rpb1 Interaction (SRI) domain are located at the C-terminal end.

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